Beilstein J. Nanotechnol.2014,5, 1699–1711, doi:10.3762/bjnano.5.180
dynamical change during AuNP translocation in fluids and across membranes within the organism.
Keywords: biokinetics; gold nanoparticles; protein corona; protein–nanoparticle conjugate; serumproteinbinding; surface modification; Introduction
Like any foreign material that enters into the organism
surface and found that in case of the hydrophobic particles the coverage was rather complete whereas only a very tiny surface percentage of the hydrophilic particles was covered (Table 1).
Serumproteinbinding during in vitro incubation of differently sized AuNP
In a second attempt we investigated the
, surface area and curvature of the AuNP [7].
Serumproteinbinding of 5 nm sized AuNP with different surface modifications
In our next attempt we hypothesized that the configuration of the protein corona (composition, size, geometric orientation) depends on the surface ligands present on the AuNP
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Figure 1:
Bovine serum albumin (BSA) depletion in the supernatant after BSA separation from the 50 nm Polysty...